What Is Selank?
Selank (TKPRPGP) is a synthetic heptapeptide derived from the sequence of tuftsin, a naturally occurring immunomodulatory tetrapeptide (TKPR). The Institute of Molecular Genetics of the Russian Academy of Sciences developed Selank as a more stable, longer-acting analogue by adding three additional amino acids (PGP) to the tuftsin sequence. This modification significantly extended the peptide's half-life while preserving and expanding its biological activity.
Selank has been registered as a pharmaceutical in Russia under the brand "Selank" for the treatment of anxiety disorders and phobias, representing one of the few research peptides with an established clinical history in human use.
Mechanism of Action
GABAergic Modulation
The most studied mechanism for Selank's anxiolytic properties involves enhancement of GABAergic neurotransmission. Preclinical data suggests Selank increases the expression and activity of GABA-A receptors in the amygdala and hippocampus โ brain regions central to anxiety processing. This mechanism is distinct from benzodiazepines in that it appears to modulate rather than flood the system.
BDNF Upregulation
Multiple studies document Selank-induced upregulation of Brain-Derived Neurotrophic Factor (BDNF). BDNF plays a critical role in neuronal survival, synaptic plasticity, and learning and memory consolidation. This effect is thought to underpin Selank's observed nootropic properties in preclinical models.
Serotonin and Dopamine Interactions
Selank has been shown in some studies to influence serotonin metabolism and dopamine turnover in the prefrontal cortex. The precise nature of these interactions is still being characterized, but they are consistent with the compound's anxiolytic and mood-stabilizing profile in animal models.
Immunomodulatory Effects
Given its tuftsin origin, Selank retains immunomodulatory activity. Research has documented its effects on IL-6, TNF-alpha, and interferon production โ suggesting a bidirectional link between its central and peripheral effects.
Research Findings Summary
| Area | Model | Key Observation |
|---|---|---|
| Anxiety (anxiolytic) | Rat (elevated plus maze) | Significant reduction in anxiety behaviors |
| Memory / Learning | Rat | Improved maze performance and memory consolidation |
| BDNF Expression | Rat brain tissue | Elevated BDNF in hippocampus and cortex |
| Immune Modulation | Mouse | Balanced IL-6 and interferon expression |
| Depression-like Behavior | Rat (forced swim test) | Reduced immobility time |
Storage & Handling
Selank is typically supplied as a lyophilized powder. Store at โ20ยฐC before reconstitution. After reconstitution with bacteriostatic water, refrigerate at 2โ8ยฐC and use within 30 days. Protect from light.
For research use only. Not for human or animal use. Order Selank here.