What Is NAD+?
NAD+ is nicotinamide adenine dinucleotide, a coenzyme present in every living cell that carries electrons in metabolism and serves as a substrate for sirtuins, PARPs and CD38. Because cellular NAD+ levels are a central readout in metabolic and aging research, purified NAD+ is widely used as a laboratory reagent.
| Property | Value |
|---|---|
| Full name | Nicotinamide adenine dinucleotide (oxidized form) |
| Class | Dinucleotide coenzyme (not a peptide) |
| Molecular formula | C₂₁H₂₇N₇O₁₄P₂ |
| Molecular weight | ~663.4 g/mol |
| Studied in | Sirtuin, PARP and CD38 pathways; mitochondrial and cellular-energy research |
| Handling note | Hygroscopic and light-sensitive: keep sealed, cold and dark |
Pathway detail: NAD+ research guide.
How Much Does NAD+ 500mg Cost?
Research-grade NAD+ 500mg typically sells for about $50–$70 per vial in 2026. Evo Peptides sells it for $49.95, at the bottom of that range, with measured content above label on the current lot.
| Measure | Value | How it's calculated |
|---|---|---|
| Price per vial | $49.95 | Current list price |
| Cost per labeled mg | $0.10 | $49.95 ÷ 500mg |
| Cost per 100mg tested | $9.80 | $49.95 ÷ 509.62mg measured (lot EP-NAD500-2) |
| Shipping | $0 at $200+ | Free shipping on orders of $200 or more |
What an NAD+ COA Should Show
An NAD+ COA should show HPLC purity, identity, measured content against the 500mg label, and a recent test date. Here is the current Evo Peptides result:
| Test | Result | What it tells you |
|---|---|---|
| HPLC purity | 99.46% | How much of the sample is NAD+ |
| Identity | NAD+ confirmed | The vial holds the right compound |
| Measured content | 509.62mg | At or above the 500mg label |
| Endotoxin | 0.154 EU/mL | Bacterial endotoxin level reported |
Full certificate: COA library. Method: How to Read a Peptide COA.
NAD+ vs NMN vs NR
NMN and NR are precursors the cell converts into NAD+; NAD+ is the coenzyme itself. Studies that need to control NAD+ directly use NAD+; studies of the biosynthetic pathway use the precursors.
| Compound | What it is | Relationship to NAD+ |
|---|---|---|
| NAD+ | The coenzyme itself | The end molecule researchers measure |
| NMN (nicotinamide mononucleotide) | Nucleotide precursor | Converted to NAD+ in one step |
| NR (nicotinamide riboside) | Nucleoside precursor | Converted to NMN, then NAD+ |
| NAM (nicotinamide) | Vitamin B3 form | Recycled into NAD+ via the salvage pathway |
6-Point NAD+ Supplier Checklist
- Lot-matched COAThe lot on the COA matches your vial.
- HPLC purity ≥99%NAD+ degrades to nicotinamide and ADP-ribose; purity shows how much is left intact.
- Measured content ≥500mgConfirms the label.
- Recent test dateNAD+ is less stable than most peptides, so recency matters more.
- Sealed, light-protected packagingMoisture and light speed degradation.
- Strict RUO labelingNo human-use or therapeutic claims.
How to Store NAD+
- Keep it dry. NAD+ is hygroscopic; leave the vial sealed until use.
- Keep it cold and dark. −20 °C long-term or 2–8 °C short-term, boxed away from light.
- After reconstitution: refrigerate, aliquot, and use promptly; NAD+ in solution degrades faster than lyophilized peptides.
More in the storage guide. For longevity-pathway context, see Peptides in Longevity Research 2026.
NAD+ + GHK-Cu + KLOW
NAD+ 500mg ($49.95), GHK-Cu 50mg ($34.95) and KLOW 80mg ($89.95) total $174.85. Add a second NAD+ vial ($224.80) to clear free shipping at $200.